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Addison is continuing to own Alex and he's upset about it.

Meredith and Cristina continue to argue about their research and careers, Bailey comes clean to Ben about her feelings regarding him moving back to Seattle, and Shane puts himself in a risky situation.

Derek and Addison are experiencing their own version of morning-after tension as a result of Mark's visit to Seattle.

What if she had never met Derek in that bar and he had never separated from Addison? Meanwhile, Derek feels overwhelmed between his responsibilities at home and at the hospital.

Owen bonds with a young boy whose parents are in critical condition.

Meanwhile, Maggie tries to reach Teddy after bearing the burden of her secret becomes overwhelming as she struggles with issues in her own personal life.

George impresses the other interns at work but at home he is trying to deal with his guilt about having sex with Izzie.

George lies to the woman whose son he had been looking for, in order to get to surgery, but still doesn't have any luck in locating him.

Two foster patients are met with suspicions of child abuse.

Meanwhile, Alex treats Devo, a patient whose religious beliefs jeopardize her chances for recovery; Izzie contemplates reconnecting with her estranged mother; Zoey, a pregnant woman in her 40s who's been diagnosed with cancer, disagrees with Cristina's medical advice; and the interns are mystified by Cable, a patient who's being treated for seizures and who thinks he's psychic.

The residents agonize over their oral boards, reliving every answer they gave during their exams; Arizona's close childhood friend comes to Seattle Grace for medical help; the doctors work on a patient who is missing one third of his skull; and Julia asks Mark to start a family with her.

Izzie seeks advice from Addison about her affair, telling her sleeping with George felt right, despite him being married.